Age-related macular degeneration (AMD) is a leading cause of blindness among individuals 50 and older in the United States, with an estimated prevalence of 5.4 million cases by 2050. Hallmarks of AMD— including drusen, ret i nal pigment epithelium (RPE) changes, choroidal neovascularization (CNV), and disciform scarring— are all-too-familiar findings in daily ophthalmic practice. These clinical signs, however, are not exclusive to AMD. Masquerade syndromes of AMD are a heterogeneous group of ret i nal pathologies with clinical pre sen ta tions overlapping with AMD, but they arrive at sometimes perplexingly similar clinical phenotypes via distinct pathways. Given the significant differences in clinical course, management, and prognosis for these conditions, it is impor tant for an ophthalmologist to maintain clinical suspicion in cases of aty pi cal or treatment- resistant AMD. The following discussion broadly categorizes AMD masquerade syndromes based on their resemblance to nonexudative (dry) versus exudative (wet) AMD, while recognizing overlapping conditions. The goal is to aid ophthalmologists in differentiating these ret i nal conditions from typical AMD in clinical practice.